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Buffalo Bills running back LeSean McCoy (25) runs past Jacksonville Jaguars' Johnathan Cyprien (37) for a touchdown during the second half of an NFL football game Sunday, Nov. 27, 2016, in Orchard Park, N.Y. (AP Photo/Bill Wippert)

ORCHARD PARK, N.Y. (AP) — LeSean McCoy scored twice, including a career-best 75-yard run, and the Buffalo Bills won their second in a row by beating the Jacksonville Jaguars 28-21 on Sunday.