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Of all the challenges now confronting Houston Texans quarterback Brock Osweiler, one of the most significant has to do with his confidence, according to league sources.

NFL executives and coaches who have watched Osweiler play believe he has lost his confidence, and it has affected his play. They pointed to one particular throw during Monday night’s loss to his former team, the Denver Broncos, when Osweiler had one of his tight ends wide open and missed him by about three yards.

One source said he believed Osweiler’s inaccuracy is a direct result of the lost confidence.

Osweiler was playing in Denver for the first time since leaving to sign a four-year, $72 million contract with the Texans during the offseason. He finished 22-for-41 for 131 yards without a touchdown and also fumbled early in the fourth quarter to put the game out of reach for Houston.

This season he is completing 58.2 percent of his passes.

Texans head coach Bill O’Brien is one of the league’s top quarterback gurus, but also is demanding, as Patriots quarterback Tom Brady learned.

O’Brien’s demanding style could be having a counterproductive effect on Osweiler, but even if it isn’t, those who have watched the Texans quarterback believe he is playing without any confidence.

Information from ESPN Texans reporter Sarah Barshop was used in this report.